Chondroitin sulfate is a biological macromolecule. Chemically, chondroitin is a mixture of sulfated glycosaminoglycans, also called mucopolysaccharides. In the polymer chains, the sugar derivatives N-acetylgalactosamine and glucuronic acid alternate. A chondroitin chain can consist of more than 100 sugar units, which can vary in strength and be sulphated at positions C6 and/or C4 of GalNAc.

protein binding

Biologically, chondroitin sulphate is usually bound to proteins as part of a proteoglycan. The chondroitin sulfate chains are bound to the hydroxy groups of the serine residues of certain proteins. How exactly the proteins are selected for binding with glycosaminoglycans is not yet understood in chondroitin. Glycosylated serine residues often follow glycine residues, acidic amino acid residues are found in the vicinity.

Chondroitin Sulfate is an active ingredient from the group of sulfated glycosaminoglycans, which is used for the treatment of arthrosis. Chondroitin is a natural component of proteoglycans in the extracellular matrix of cartilage. Depending on the preparation, chondroitin is taken one to three times a day independently of meals. Possible adverse effects include occasional indigestion such as nausea and constipation.

In rare cases, chondroitin can cause allergic reactions.

Chondroitin products may differ because they are obtained from different animals and with different processing methods.

Structure and properties of chondroitin

Chondroitin Sulfate is a natural glycosaminoglycan and a copolymer consisting of repeating sulfated disaccharides of N-acetyl-D-galactosamine and D-glucuronic acid. Chondroitin is a long, linear polysaccharide with a high molecular weight.

Effects of Chondroitin

Chondroitin Sulfate has analgesic, antioxidant, immunomodulating and anti-inflammatory properties. It is an endogenous substance and a component of the proteoglycans found in the extracellular matrix of cartilage.

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